Several members of the Hes/Her family, conserved targets of the Notch signalling pathway, encode transcriptional repressors that dimerise, bind DNA and self-repress.Such autoinhibition of transcription can yield homeostasis and, in the presence of delays that account for processes such as transcription, splicing and transport, oscillations.Whilst p
INTRODUCTION:Chronic pancreatitis (CP) may be caused by oxidative stress.An important source of reactive oxygen species (ROS) is the methylglyoxal-derived formation of advanced glycation endproducts (AGE).Methylglyoxal is detoxified by Glyoxalase I (GLO1).A reduction in GLO1 activity results in increased ROS.Single nucleotide polymorphisms (SNPs) o
A software-defined network (SDN) is a new architecture approach for constructing and maintaining networks with the main goal of making the network open and programmable.This allows the achievement of specific network behavior by updating and installing software, instead of making physical changes to the network.Thus, SDNs allow far more flexibility
In recent years, the increasing number of autistic patients has attracted the attention of governments around the world.Normerally, experts will use counseling strategies, drug treatment methods, or the Squeeze Machine, which designed on the basis of the sensory integration theory, to improve those autistic patients’ stereotypical behaviors perfo